Here, we investigated the evolutionary history of a common polymorphism resulting in a T529 versus C529 change in the Cadherin-Related Family Member 3 (CDHR3) receptor which underlies variable susceptibility to rhinovirus-C infection and is associated with severe childhood asthma.
Our objective was to determine if NAT1 polymorphisms confer increased risk for developing asthma in children exposed to SHS.<b>Methods:</b> White participants in the Cincinnati Childhood Allergy and Air Pollution Study (<i>n</i> = 359) were genotyped for 10 <i>NAT1</i> variants.
Strong LD was found among rs678881, rs2280089 and rs2853209, and haplotype GGT was distinctly associated with the risk of asthma in children (OR = 0.28, 95%CI = 0.13-0.57).ADAM33rs678881 polymorphism is significantly correlated with increased susceptibility to asthma in Chinese Han children.
Increased serum levels of IL-33 is related with keeping cats during pregnancy and in early childhood and can be associated with the development of asthma in children.
The PTS exposure doses at 0, <20, and ≧20 cigarettes per day were significantly associated with the trend of childhood asthma and the increase of <i>LMO2-E148</i> (<i>p</i> = 0.006), and <i>IL10_P325</i> (<i>p</i> = 0.008) <i>CG</i> methylation.
Adiponectin, leptin, and BMI are involved in the pathogenesis of asthma in children, suggesting they might be therapeutic targets for clinical treatment.
Adiponectin, leptin, and BMI are involved in the pathogenesis of asthma in children, suggesting they might be therapeutic targets for clinical treatment.
Fractional Exhaled Nitric Oxide (FeNO) Combined with Pulmonary Function Parameters Shows Increased Sensitivity and Specificity for the Diagnosis of Cough Variant Asthma in Children.